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Biochemistry IV - Biophysical Chemistry - Prof. Dr. Janosch Hennig

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New publication in ChemBioChem

12.02.2025

This article is the view of the chairholder about structural biology of RNA and protein-RNA complex after the advent of machine learning-based prediction tools. While they are working like a charm for single proteins and quite well for protein complexes, they fail for protein-RNA complexes and RNA. Currently, these predictions need to be evaluated carefully as they often are not even good enough as a research hypothesis but outright misleading. Surely, this will be improved over the coming years.

Structural biology of RNA and protein-RNA complexes after AlphaFold3

Janosch Hennig

ChemBioChem DOI: 10.1002/cbic.202401047
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