News
New publication in Nucleic Acids Research
18.11.2024
Janosch Hennig’s final postdoc paper has finally been published (after more than 9 years of not being a postdoc anymore), despite having a manuscript already 10 years ago. This is how it can go…
However, the story is highly interesting and among other insights links a potential early RNA world to a RNA-peptide world and shows that biomolecular condensation by liquid-liquid phase separation could be a likely scenario for enabling an RNA world and life in the first place.
This scheme illustrates how certain positively charged, unstructured nucleic acid binding (PUN) motifs bind to RNA and induce liquid droplet formation.
This scheme illustrates how certain positively charged, unstructured nucleic acid binding (PUN) motifs bind to RNA and induce liquid droplet formation.
Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation
Annika Niedner-Boblenz, Thomas Monecke, Janosch Hennig, Melina Klostermann, Mario Hofweber, Elena Davydova, André P. Gerber, Irina Anosova, Wieland Mayer, Marisa Müller, Roland Gerhard Heym, Robert Janowski, Jean-Christophe Paillart, Dorothee Dormann, Kathi Zarnack, Michael Sattler and Dierk Niessing.