News

Congratulations to Lucía and all of us who contributed to this exciting article published in Nature Communications. An amazing collaboration with Alfredo Castello’s lab at the Centre for Virus Research, University of Glasgow and with 8 other institutes in 5 countries (also special thanks to Fred Allain’s lab at ETH Zürich for sharing very important data derived from CLIR-MS/MS). Using a wide range of methods, combining biophysics with iCLIP2, fluorescence microscopy and viral fitness assays, we could show that structure- and sequence-specific RNA binding by TRIM25 is essential for TRIM25’s antiviral activity against human-pathogenic Sindbis virus. Lucía did an amazing job, doing most of the experiments and coordinating a large part of this study.