News
New publication in EMBO J
06.03.2024
In this collaboration with Sagar Bhogaraju at EMBL Grenoble, Lucía (congratulations!) could contribute to our understanding of the mechanism of action of MAGE protein. MAGE proteins bind RING ubiquitin ligases and often promote pro-oncogenic pathways. Through structural and biochemical approaches, this study gives insight into how MAGEA4 binds and regulates the RING E3 RAD18, which is crucial for DNA repair. We used NMR spectroscopy to validate an AlphaFold2-Multimer model of the MAGEA4-MHD-RAD18-R6BD complex.
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Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins
Simonne Griffith-Jones, Lucía Álvarez, Urbi Mukhopadhyay, Sarah Gharbi, Mandy Rettel, Michael Adams, Janosch Hennig and Sagar Bhogaraju.