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Biochemistry IV - Biophysical Chemistry - Prof. Dr. Janosch Hennig

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New publication in Nature Structural & Molecular Biology

31.01.2024

Fruitful collaboration with Simone Heber and Anne Ephrussi @EMBL. The next step towards understanding RNA transport. Here, Simone could show how Tropomyosin prevents a Tug-of-War between Kinesin- and Dynein-mediated transport to bring the RNA cargo to the right place for translation (here: oskar mRNA from the nurse cells to the posterior pole of the oocyte in a Drosophila embryo). She could reconstitute active transport in vitro to visualize this process using TIRF microscopy. We contribute NMR and SAXS data to derive a structural model of a full-length Kinesin-Tropomyosin complex.

Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport

Simone Heber, Mark A. McClintock, Bernd Simon, Eve Mehtab, Karine Lapouge, Janosch Hennig, Simon L. Bullock & Anne Ephrussi.

Nature Structural & Molecular Biology DOI: https://doi.org/10.1038/s41594-024-01212-x

Pressemitteilung der Uni Bayreuth:
https://www.uni-bayreuth.de/en/press-release/mRNA-transport

News-Artikel des EMBL:  Link

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